GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs7714584 | 1 | rs7732643 | chr5:150261436 | LOC134466 | chr5:150310000-150326146:- | 0.46 | 6.12 | 2.36E-9 | Crohn's disease |
| BLCA | cis | rs7714584 | 1 | rs7732945 | chr5:150261601 | LOC134466 | chr5:150310000-150326146:- | 0.47 | 6.2 | 1.42E-9 | Crohn's disease |
| BLCA | cis | rs6951245 | 1 | rs77346188 | chr7:1114023 | ZFAND2A | chr7:1192544-1199855:- | -0.38 | -4.43 | 1.26E-5 | C-reactive protein levels or total cholesterol levels (pleiotropy) |
| BLCA | cis | rs7714584 | 1 | rs7734778 | chr5:150256556 | LOC134466 | chr5:150310000-150326146:- | 0.46 | 6.06 | 3.23E-9 | Crohn's disease |
| BLCA | cis | rs7714584 | 1 | rs7734928 | chr5:150256613 | LOC134466 | chr5:150310000-150326146:- | 0.48 | 6.27 | 9.54E-10 | Crohn's disease |
| BLCA | cis | rs7714584 | 1 | rs7736554 | chr5:150258308 | LOC134466 | chr5:150310000-150326146:- | 0.47 | 6.22 | 1.33E-9 | Crohn's disease |
| BLCA | cis | rs7714584 | 1 | rs7736873 | chr5:150258482 | LOC134466 | chr5:150310000-150326146:- | 0.47 | 6.22 | 1.33E-9 | Crohn's disease |
| BLCA | cis | rs853679 | 1 | rs7740487 | chr6:28216486 | ZNF389 | chr6:28129551-28137375:+ | -0.33 | -4.07 | 5.63E-5 | Depression |
| BLCA | cis | rs17138114 | 1 | rs7747061 | chr6:4381445 | CDYL | chr6:4706393-4955777:+ | -0.34 | -3.88 | 0.000123 | Obesity-related traits |
| BLCA | cis | rs1577917 | 1 | rs7747824 | chr6:86647106 | SNHG5 | chr6:86386726-86388451:- | -0.56 | -10.22 | 7.52E-22 | Response to antipsychotic treatment |
| BLCA | cis | rs9473555 | 1 | rs7750918 | chr6:49430082 | CENPQ | chr6:49431096-49460820:+ | -0.28 | -5.67 | 2.85E-8 | Folate pathway vitamin levels |
| BLCA | cis | rs9473555 | 1 | rs7750918 | chr6:49430082 | MUT | chr6:49398994-49431031:- | 0.26 | 5.05 | 6.69E-7 | Folate pathway vitamin levels |
| BLCA | cis | rs78153629 | 1 | rs77531164 | chr15:40673466 | C15orf23 | chr15:40674922-40686488:+ | 0.32 | 5.57 | 4.84E-8 | Heschl's gyrus morphology |
| BLCA | cis | rs1577917 | 1 | rs7756203 | chr6:86627707 | SNHG5 | chr6:86386726-86388451:- | -0.51 | -9.01 | 9.54E-18 | Response to antipsychotic treatment |
| BLCA | cis | rs9369898 | 1 | rs7759071 | chr6:49433198 | CENPQ | chr6:49431096-49460820:+ | -0.41 | -8.97 | 1.37E-17 | Homocysteine levels |